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Immune response |
The Effect Of Endovascular Laser
Therapy And Antioxidants On The Immune Status And
Energy Metabolism Of Patients With
Treatment-Resistant Forms Of Schizophrenia
Kut'ko II, Frolov VM, Pustovoi IuG, Pavlenko VV,
Rachkauskas GS.
Zh Nevropatol Psikhiatr Im S S Korsakova.
1996;96(2):34-8.
The influence of endovascular laser therapy and of
antioxidants on clinical immunological indices
and energy metabolism was analysed in 148
schizophrenic patients including 86 patients with
shift-like progredient (first group) and 62 patients
with continuous-progredient (second group)
forms of the disease. Positive trends in psychosis
course were observed in 57% of cases in the
first group and in 41.9% of patients of the second
group. Pronounced improvement of the
immunological indices was observed in patients with
positive clinical dynamics: decreased
peripheral blood immunocytes sensitization to the
brain, hepatic, thymus tissue antigens as well
as ATP elevation which was evidence of the
improvement of energy metabolism.
Immunomodulatory Effect
Of Laser On Whole Body Exposure
Ganju L, Salhan A, Karan D, Chanda S, Srivastava KK.
Indian J Exp Biol. 1999 May;37(5):444-9.
Defence Institute of Physiology & Allied Sciences,
Timarpur, Delhi, India. All biomedical laser
applications are based on the interaction of laser
light with biological system. During the past
decade considerable evidence has accumulated
demonstrating that non-thermal exposure to
laser can elicit cellular changes in the immune
system. In the present study, we have analyzed
the effect of laser on immune response in rats. A
group of rats were exposed to 0.225 mu j/cm2
for 90 min for 3 days in specially designed
fiberglass chambers. The whole body exposure of rats
of He-Ne laser modulated both the humoral and
cellular responses to tetanus toxoid stimulation.
Plain red light used as a control for red laser
light showed an appreciable degree of response as
compared to the control groups, but not to the
extent of the response to laser. Non-responders
turned responders after exposure to laser. There was
no response in unimmunized groups when
exposed to laser and red light alone.
The early and heightened immune
response and proliferation of lymphocytes after
exposure to laser is suggestive of a complex
interaction at the cellular immune response level.
Low-Level Laser Irradiation
Attenuates Production Of Reactive Oxygen Species By
Human
Neutrophils
Fujimaki Y, Shimoyama T, Liu Q, Umeda T, Nakaji S,
Sugawara K.
Department of Hygiene, Hirosaki University School of
Medicine, Japan.
J Clin Laser Med Surg. 2003 Jun;21(3):165-70.
OBJECTIVE: The aim of this study was to examine the
effects of low-level laser therapy (LLLT)
on production of reactive oxygen (ROS) species by
human neutrophils.
BACKGROUND DATA: LLLT is an effective therapeutic
modality for inflammatory conditions.
MATERIALS AND METHODS: The laser device used was the
infrared diode laser (GaAlAs), 830-nm continuous
wave (150 mW/cm(2)). After irradiation, ROS
production by neutrophils was
measured using luminol-dependent chemiluminescence (LmCL)
and expression of CD11b and
CD16 on neutrophil surface was measured by flow
cytometry.
RESULTS: The LmCL response of neutrophils was
reduced by laser irradiation at 60 min prior to
the stimulation with opsonized zymosan and calcium
ionophore. The attenuating effect of LLLT
was larger in neutrophils of smokers than
non-smokers, while the amount of produced ROS was
larger in neutrophils of smokers. Expression of
CD11b and CD16 on neutrophil surface was not
affected by LLLT.
CONCLUSION: Attenuation of ROS production by
neutrophils may play a role in the effects of
LLLT in the treatment of inflammatory tissues. There
is a possible usage of LLLT to improve
wound healing in smokers. |
